Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells (Record no. 43162)

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fixed length control field 01669nam a2200229Ia 4500
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control field MX-MdCICY
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control field 20250625124728.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8900
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Title Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells
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Volume/sequential designation BioChemical Pharmacology, 59(4), p.317-320, 2000
520 3# - SUMMARY, ETC.
Summary, etc. Granulysin is a novel antimicrobial protein produced by human cytolytic T lymphocytes and natural killer cells. It is active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. The fact that it kills Mycobacterium tuberculosis is particularly important, since the current vaccine (Bacille Calmette-Guerin, BCG)is of limited efficacy and antibiotic resistance is increasing. Although functionally related to other antibacterial peptides, defensins and magainins, granulysin is structurally distinct. Like porcine NK lysin and amoebapores made by Entamoeba histolytica, granulysin is related to saposins, small lipid-associated proteins present in the central nervous system. The identification of this novel molecule indicates a broader and perhaps more significant role for T lymphocytes in both innate and acquired antimicrobial defenses.
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Topical term or geographic name entry element CYTOLYTIC T LYMPHOCYTE
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Topical term or geographic name entry element NATURAL KILLER CELL
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Topical term or geographic name entry element ANTIBIOTIC
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Topical term or geographic name entry element PEPTIDES
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Topical term or geographic name entry element GRANULYSIN
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Krensky, A.M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1I1Z-ZL-RbtxQstaUUUzyR4LT7zWbhoJd/view?usp=drivesdk">https://drive.google.com/file/d/1I1Z-ZL-RbtxQstaUUUzyR4LT7zWbhoJd/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8900 25.06.2025 25.06.2025 Documentos solicitados