The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata (Record no. 43254)

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003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625124730.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8994
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245 10 - TITLE STATEMENT
Title The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata
490 0# - SERIES STATEMENT
Volume/sequential designation PhytoChemistry, 67(18), p.2071-2077, 2006
520 3# - SUMMARY, ETC.
Summary, etc. The importance of flavonoids for the antileishmanial activity of Kalanchoe pinnata was previously demonstrated by the isolation of quercitrin, a potent antileishmanial flavonoid. In the present study, the aqueous leaf extract from the medicinal plant K. pinnata (Crassulaceae)afforded a kaempferol di-glycoside, named kapinnatoside, identified as kaempferol 3-O-a-L-arabinopyranosyl (1! 2)a-Lrhamnopyranoside (1). In addition, two unusual flavonol and flavone glycosides already reported, quercetin 3-O-a-L-arabinopyranosyl (1! 2)a-L-rhamnopyranoside (2)and 40,5-dihydroxy-30,8-dimethoxyflavone 7-O-b-D-glucopyranoside (3), have been isolated. Their structures were determined via analyses of mono and bi-dimensional 1H and 13C NMR spectroscopic experiments and HR-MALDI mass spectra. Because of its restricted occurrence and its abundance in K. pinnata, flavonoid (2)may be a chemical marker for this plant species of high therapeutic potential. The three flavonoids were tested separately against Leishmania amazonenis amastigotes in comparison with quercitrin, quercetin and afzelin. The quercetin aglycone - type structure, as well as a rhamnosyl unit linked at C-3, seem to be important for antileishmanial activity.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element KALANCHOE PINNATA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CRASSULACEAE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element LEISHMANIASIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NMR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FLAVONOIDS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element KAEMPFEROL 3-O-A-L-ARABINOPYRANOSYL (1!2)A-L-RHAMNOPYRANOSIDE
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Muzitano, M.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tinoco, L.W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Guette, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kaiser, C.R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rossi-Bergmann, B.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1-FXRN0T6k71yGnavdvi9Wakx-Qd_h4XD/view?usp=drivesdk">https://drive.google.com/file/d/1-FXRN0T6k71yGnavdvi9Wakx-Qd_h4XD/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8994 25.06.2025 25.06.2025 Documentos solicitados