Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes (Record no. 43281)

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control field 20250625124731.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9021
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Title Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes
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Volume/sequential designation Current Opinion in Cell Biology, 19(4), p.459-465, 2007
520 3# - SUMMARY, ETC.
Summary, etc. The pathways that deliver newly synthesized proteins that reside in lysosomes are well understood on comparison with our knowledge of how integral membrane proteins are sorted and delivered to the lysosome for degradation. Many membrane proteins are sorted to lysosomes following ubiquitination, which provides a sorting signal that can operate for sorting at the TGN (trans-Golgi network), at the plasma membrane or at the endosome for delivery into lumenal vesicles. Candidate multicomponent machines that can potentially move ubiquitinated integral membrane cargo proteins have been identified, but much work is still required to ascertain which of these candidates directly recognize ubiquitinated cargo and what they do with cargo after recognition. In the case of the machinery required for sorting into the lumenal vesicles of endosomes, other functions have also been determined including a link between sorting and movement of endosomes along microtubules.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Piper, R.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Luzio, J.P.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/11AvFJWDvuBxjDpr-bYmu-FemOVKS9eaz/view?usp=drivesdk">https://drive.google.com/file/d/11AvFJWDvuBxjDpr-bYmu-FemOVKS9eaz/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9021 25.06.2025 25.06.2025 Documentos solicitados