Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells (Record no. 43400)

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fixed length control field 02308nam a2200289Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625124733.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9142
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245 10 - TITLE STATEMENT
Title Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells
490 0# - SERIES STATEMENT
Volume/sequential designation Food and Chemical Toxicology, 45(1), p.119-124, 2006
520 3# - SUMMARY, ETC.
Summary, etc. Antioxidative as well as cytotoxic effects of the prenylated flavonoids licoflavone C (8-prenylapigenin)and isobavachin (8-prenylliquiritigenin)were investigated in comparison to the corresponding non-prenylated flavonoids (apigenin, liquiritigenin)and vitexin (apigenin-C8-glucoside)using metabolically active H4IIE hepatoma and metabolically poorly active C6 glioma cells. None of the substances showed radical scavenging activities in the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-assay nor were they effective in protection against H2O2-induced intracellular 20,70-dichlorodihydrofluorescein (H2DCF)oxidation (fluorescent probe for oxidative stress)in H4IIE and C6 cells. When the intrinsic effects of the substances were investigated, licoflavone C and isobavachin exerted a pronounced toxicity in both H4IIE (IC50 values of 42 ± 5 and 96 ± 19 lmol/L)and C6 cells (IC50 values of 37 ± 6 and 69 ± 3 lmol/L)while the non-prenylated analogues as well as the glycosylated derivate vitexin showed almost no cytotoxic effect up to 250 lmol/L. In H4IIE cells the induction of apoptotic cell death by licoflavone C and icobavachin was detected as an activation of caspase 3/7 (6- and 3.3-fold, respectively). Based on these experiments we suggest that C8-prenylation of a flavonoid enhances the cytotoxicity inducing an apoptotic cell death in H4IIE cells without affecting antioxidative properties.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element APOPTOSIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CYTOTOXICITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DPPH ASSAY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element OXIDATIVE STRESS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Watjen, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Weber, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lou, YJ.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, ZQ.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chovolou, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kampkotter, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Proksch, P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1ClvBmkLpxqOstTKHFjYcyZNTGHSQevyq/view?usp=drivesdk">https://drive.google.com/file/d/1ClvBmkLpxqOstTKHFjYcyZNTGHSQevyq/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9142 25.06.2025 25.06.2025 Documentos solicitados