Synthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalconeA (Record no. 43401)

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control field 20250625124733.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9143
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Title Synthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalconeA
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Volume/sequential designation European Journal of Medicinal Chemistry, 39(11), 2004
520 3# - SUMMARY, ETC.
Summary, etc. In this paper, a general applicable synthesis of prenylated aromatic compounds exemplified by prenylated benzaldehydes starting from readily available acetophenones is described. The synthesized benzaldehydes are used to prepare a number of novel analogues of Licochalcone A, a known antibacterial compound, and for the exploration of the pharmacophoric elements that are essential for the antibacterial activity. It is shown that the hydroxyl group in the A ring is essential for the activity and that the hydroxyl group in the B ring has no influence on the antibacterial effect of Licochalcone A. Furthermore, it is shown that the prenyl group at the position 5 f the B ring also has a dominating influence on the activity. This aliphatic group can be replaced by other lipophilic long chained substituents in order to maintain the activity.
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Personal name Kromann, H.
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Personal name Larsen, M.
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Personal name Boesen, T.
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Personal name Schønning, K.
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Personal name Nielsen, S.F.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1rYcBZ0aWL7DjHRkMzOxu7UJy02Q2EOFv/view?usp=drivesdk">https://drive.google.com/file/d/1rYcBZ0aWL7DjHRkMzOxu7UJy02Q2EOFv/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9143 25.06.2025 25.06.2025 Documentos solicitados