The Arabidopsis Mitogen-Activated Protein Kinase Kinase MKK3 Is Upstream of Group C Mitogen-Activated Protein Kinases and Participates in Pathogen Signaling (Record no. 43540)

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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9288
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Title The Arabidopsis Mitogen-Activated Protein Kinase Kinase MKK3 Is Upstream of Group C Mitogen-Activated Protein Kinases and Participates in Pathogen Signaling
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Volume/sequential designation The Plant Cell, 19(10), p.3266-3279, 2007
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Summary, etc. Although the Arabidopsis thaliana genome contains genes encoding 20 mitogen-activated protein kinases (MAPKs)and 10 MAPK kinases (MAPKKs), most of them are still functionally uncharacterized. In this work, we analyzed the function of the group B MAPK kinase, MKK3. Transgenic ProMKK3:GUS lines showed basal expression in vascular tissues that was strongly induced by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000)infection but not by abiotic stresses. The growth of virulent Pst DC3000 was increased in mkk3 knockout plants and decreased in MKK3-overexpressing plants. Moreover, MKK3 overexpression lines showed increased expression of several PR genes. By yeast two-hybrid analysis, coimmunoprecipitation, and protein kinase assays, MKK3 was revealed to be an upstream activator of the group C MAPKs MPK1, MPK2, MPK7, and MPK14. Flagellin-derived flg22 peptide strongly activated MPK6 but resulted in poor activation of MPK7. By contrast, MPK6 and MPK7 were both activated by H2O2, but only MPK7 activation was enhanced by MKK3. In agreement with the notion that MKK3 regulates the expression of PR genes, ProPR1:GUS expression was strongly enhanced by coexpression of MKK3-MPK7. Our results reveal that the MKK3 pathway plays a role in pathogen defense and further underscore the importance and complexity of MAPK signaling in plant stress responses.
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Personal name Doczi, R.
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Personal name Brader, G.
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Personal name Pettko-Szandtner, A.
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Personal name Rajh, I.
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Personal name Djamei, A.
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Personal name Pitzschke, A.
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Personal name Teige, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Teige, M.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1VEOQG_FNaelQtHyX2tHAOiKGbpdMdEqu/view?usp=drivesdk">https://drive.google.com/file/d/1VEOQG_FNaelQtHyX2tHAOiKGbpdMdEqu/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9288 25.06.2025 25.06.2025 Documentos solicitados