Platelet-activating factor (PAF)receptor binding antagonists from Alpinia officinarum (Record no. 43558)

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control field MX-MdCICY
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control field 20250625140610.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9307
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Title Platelet-activating factor (PAF)receptor binding antagonists from Alpinia officinarum
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Volume/sequential designation Bioorganic & Medicinal Chemistry Letters, 17(24), p.6720-6722, 2007
520 3# - SUMMARY, ETC.
Summary, etc. The bioassay-guided purification of ether extracts of Alpinia officinarum led to the isolation of two new compounds 6- xydroxy-1,7-diphenyl-4-en-3-heptanone (1)and 6-(2-hydroxy-phenyl)-4-methoxy-2-pyrone (4)as well as three known compounds 1,7-diphenyl-4-en-3-heptanone (2), 1,7-diphenyl-5-methoxy-3-heptanone (3), and apigenin (5). Their structures were established on the basis of spectral methods. All three diarylheptanoids 1, 2, and 3 exhibited potent PAF receptor binding inhibitory activities with an IC50 of 1.3, 5.0, and 1.6 lM, respectively. These studies have identified diarylheptanoids as a novel class of potent PAF antagonists.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fan, G.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kang, Y.H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Han, Y.N.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Han, B.H.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1SjB5Q9yjZ1pWkHPvSodr3fE_jhnCh92v/view?usp=drivesdk">https://drive.google.com/file/d/1SjB5Q9yjZ1pWkHPvSodr3fE_jhnCh92v/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9307 25.06.2025 25.06.2025 Documentos solicitados