Novel approach to fabricate porous sponges of poly(o,klactic-co-glycolic acid)without the use of organic solvents (Record no. 43597)

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fixed length control field 02097nam a2200265Ia 4500
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control field MX-MdCICY
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control field 20250625140611.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9347
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245 10 - TITLE STATEMENT
Title Novel approach to fabricate porous sponges of poly(o,klactic-co-glycolic acid)without the use of organic solvents
490 0# - SERIES STATEMENT
Volume/sequential designation BioMaterials, 17(14), p.1417-1422, 1996
520 3# - SUMMARY, ETC.
Summary, etc. A novel method was developed to produce highly porous sponges for potential use in tissue engineering, without the use of organic solvents. Highly porous sponges of biodegradable polymers are frequently utilized in tissue engineering both to transplant cells or growth factors, and to serve as a template for tissue regeneration. The processes utilized to fabricate sponges typically use organic solvents, but organic residues remaining in the sponges may be harmful to adherent cells, protein growth factors or nearby tissues. This report describes a technique to fabricate macroporous sponges from synthetic biodegradable polymers using high pressure carbon dioxide processing at room temperature. Solid discs of poly (D,L-lactic-co-glycolic acid)were saturated with COP by exposure to high pressure CO1 gas (5.5 MPa)for 72 h at room temperature. The solubility of the gas in the polymer was then rapidly decreased by reducing the CO* gas pressure to atmospheric levels. This created a thermodynamic instability for the CO2 dissolved in the polymer discs, and resulted in the nucleation and growth of gas cells within the polymer matrix. Polymer sponges with large pores (approximately 100 pm)and porosities of up to 93
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIODEGRADABLE POLYMERS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CARBON DIOXIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MACROPORES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TISSUE ENGINEERING
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mooney, D.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Baldwin, D.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Suht, N.P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Vacantis, J.P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Larger, R.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1rZPBMwzwV7cU8JDUDf8VJKcGUI-Ky5ZD/view?usp=drivesdk">https://drive.google.com/file/d/1rZPBMwzwV7cU8JDUDf8VJKcGUI-Ky5ZD/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9347 25.06.2025 25.06.2025 Documentos solicitados