Structural aspects of antioxidant activity of flavonoids (Record no. 43604)

MARC details
000 -LEADER
fixed length control field 02302nam a2200301Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625140611.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9354
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Structural aspects of antioxidant activity of flavonoids
490 0# - SERIES STATEMENT
Volume/sequential designation Free Radical Biology & Medicine, 20(3), p.331-342, 1996
520 3# - SUMMARY, ETC.
Summary, etc. Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and e2+/ascorbate (nonenzymatically)-induced microsomal lipid peroxidation (LPO)and to chelate Fe 2÷ . In addition, we measured half peak oxidation potentials (Ep/2). LPO inhibition data gave a good qualitative correlation with the oxidation potentials. Most flavonoids tested chelated Fe 2÷, but there were large differences in the chelating capacity. For good scavenging activity, a catechol moiety on ring B is required. The 3-OH moiety can function as a chelation site and can also be oxidized. The 3-OH group in combination with a C2 C3 double bond, increases the cavenging activity. Fe 2÷ chelation only plays a role in the LPO inhibition by less active scavengers. Chelation can then raise the activity to the level of the most active scavengers, possibly by site-specific scavenging. It can be concluded that Ep/2 values and iron chelating activity can almost completely describe the LPO inhibiting behaviour of the flavonoids.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FREE RADICALS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTIOXIDANT
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FLAVONOID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element OXIDATION POTENTIAL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element LIPID PEROXIDATION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Van Acker, S.A.B.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Van Den Berg, D.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tromp, M.J.L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Griffioen, D.H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Van Bennekom, W.P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Van Der Vijgh, W.J.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bast, A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1_tdzNoeHTxkRpp7MTVBQwa1LvhvEZTLN/view?usp=drivesdk">https://drive.google.com/file/d/1_tdzNoeHTxkRpp7MTVBQwa1LvhvEZTLN/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9354 25.06.2025 25.06.2025 Documentos solicitados