A nuclear receptor-like pathway regulating multidrug resistance in fungi (Record no. 43642)
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| fixed length control field | 02423nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140611.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-9392 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | A nuclear receptor-like pathway regulating multidrug resistance in fungi |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature, 452, p.604, 2008 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Multidrug resistance (MDR)is a serious complication during treatment of opportunistic fungal infections that frequently afflict immunocompromised individuals, such as transplant recipients and cancer patients undergoing cytotoxic chemotherapy. Improved knowledge of the molecular pathways controlling MDR in pathogenic fungi should facilitate the development of novel therapies to combat these intransigent infections. MDR is often caused by upregulation of drug efflux pumps by members of the fungal zinc-cluster transcription-factor family (for example Pdr1p orthologues). However, the molecular mechanisms are poorly understood. Here we show that Pdr1p family members in Saccharomyces cerevisiae and the human pathogen Candida glabrata directly bind to structurally diverse drugs and xenobiotics, resulting in stimulated expression of drug efflux pumps and induction of MDR. Notably, this is mechanistically similar to regulation of MDR in vertebrates by the PXR nuclear receptor, revealing an unexpected functional analogy of fungal and metazoan regulators of MDR. We have also uncovered a critical and specific role of the Gal11p/MED15 subunit of the Mediator co-activator and its activator-targeted KIX domain in antifungal/xenobiotic-dependent regulation of MDR. This detailed mechanistic understanding of a fungal nuclear receptor-like gene regulatory pathway provides novel therapeutic targets for the treatment of multidrug-resistant fungal infections. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thakur, J.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arthanari, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pan, S.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fan, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Breger, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frueh, D.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frueh, D.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, D.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mylonakis, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Struhl, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moye-Rowley, W.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cormack, B.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wagner, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naar, A.N. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1aX2NoJiTpOeAzT-xxSh1sL9je1nJUSYy/view?usp=drivesdk">https://drive.google.com/file/d/1aX2NoJiTpOeAzT-xxSh1sL9je1nJUSYy/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-9392 | 25.06.2025 | 25.06.2025 | Documentos solicitados |