Phytoestrogens from the Roots of Polygonum cuspidatum (Polygonaceae): Structure-Requirement of Hydroxyanthraquinones for Estrogenic Activity (Record no. 43842)
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| fixed length control field | 02010nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140615.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-9595 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Phytoestrogens from the Roots of Polygonum cuspidatum (Polygonaceae): Structure-Requirement of Hydroxyanthraquinones for Estrogenic Activity |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Bioorganic & Medicinal Chemistry Letters, 11(14), p.1839-1842, 2001 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The methanolic extract from the roots of Polygonum (P.)cuspidatum was found to enhance cell proliferation at 30 or 100 mg/mL in MCF-7, an estrogen-sensitive cell line. By bioassay-guided separation from P. cuspidatum with the most potent activity, emodin and emodin 8-O-b-d-glucopyranoside were isolated as active principles. The methanolic extracts from Polygonum, Cassia, Aloe, and Rheum species, which were known to contain anthraquinones, also showed the MCF-7 proliferation. As a result of the evaluation of various anthraquinones from plant sources and synthetic anthraquinones, aloe-emodin, chrysophanol, chrysophanol 8-O-b-d-glucopyranoside, and 1,8-dihydroxyanthraquinone showed weak activity. On the other hand, alizalin and 2,6- dihydroxyanthraquinone as well as emodin having the 2- and/or 6-hydoxyl groups showed potent activity. These results show that the unchelated hydroxyl group is essential for strong activity. Emodin and ,6-dihydroxyanthraquinone also inhibited 17b-estradiol binding to human estrogen receptors (ERs)with Ki values of 0.77 and 0.31 mM for ERa and 1.5 and 0.69 mM for ERb. These findings indicate that hydroxyanthraquinones such as emodin are phytoestrogens with an affinity to human estrogen receptors. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Matsuda, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shimoda, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Morikawa, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yoshikawa, M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1iAoqurao5CTWnd-9EYSG4xj0r8EsOPwM/view?usp=drivesdk">https://drive.google.com/file/d/1iAoqurao5CTWnd-9EYSG4xj0r8EsOPwM/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-9595 | 25.06.2025 | 25.06.2025 | Documentos solicitados |