Comparative analysis of [FeFe]hydrogenase from Thermotogales indicates the molecular basis of resistance to oxygen inactivation (Record no. 43907)

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control field MX-MdCICY
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control field 20250625140617.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9660
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Title Comparative analysis of [FeFe]hydrogenase from Thermotogales indicates the molecular basis of resistance to oxygen inactivation
490 0# - SERIES STATEMENT
Volume/sequential designation International Journal of Hydrogen Energy, 33(2), p.570-578, 2008
520 3# - SUMMARY, ETC.
Summary, etc. Several Thermotogales, previously reported as being strict anaerobes, have demonstrated the ability to grow and produce hydrogen in the presence of moderate amounts of molecular oxygen. Thermotoga neapolitana seems to be less sensitive to O2 than other members of this order, including Thermotoga maritima, whose hydrogenase has been purified and characterized. Instead, the enzyme responsible for the hydrogen production by T. neapolitana has not yet been identified. After the recent sequencing of the T. neapolitana genome, it has been possible to search for the orthologous gene responsible for this unusal hydrogenase activity. By means of in silico analysis, we built a molecular model for both T. maritima and T. neapolitana proteins and analyzed conservation, focusing on the subtle structural differences responsible for the increased oxygen resistance in the latter and underscoring two mutations (E475S and T539L)which represent a specific adaption for more effective release of hydrogen in aerobic conditions.
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Topical term or geographic name entry element BIOHYDROGEN
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Topical term or geographic name entry element HYDA
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Topical term or geographic name entry element H-CLUSTER
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Topical term or geographic name entry element HYDROPHOBIC GAS CHANNEL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FUNCTION PREDICTION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tosatto, S.C.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Toppo, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Carbonera, D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Giacometti, G.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Costantini, P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/10ipoaGpQBkKGSPJXvp822ahXrZpY4WTc/view?usp=drivesdk">https://drive.google.com/file/d/10ipoaGpQBkKGSPJXvp822ahXrZpY4WTc/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9660 25.06.2025 25.06.2025 Documentos solicitados