The development of an in vitro screening strategy for topically applied products (Record no. 44166)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01929nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140622.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-9923 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The development of an in vitro screening strategy for topically applied products |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of EthnoPharmacology, 89(1), p.81-90, 2003 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The objective of this study was the pharmaco-toxicological understanding of the constituents of an authenticated herbal mixture. The mixture was prepared by maceration in ethanol and subsequent dilution to produce a topically applied lotion, for which the intended target conditions are psoriasis and eczema. A three-tiered in vitro screening strategy was adopted for evaluating this product, comprising cytotoxicity assays; mutagenicity screening and therapeutic evaluation. Viability assays performed with dilutions of both the herbal concentrate and final product on organotypic cell lines indicated that neither preparation acted as an irritant. Genotoxicity screening using six strains of Salmonella typhimurium showed no mutagenic potential, and furthermore significant anti-microbial activity was evident. Therapeutic evaluation involved assessing the antioxidant potential of the extract, which can be correlated to an anti-inflammatory effect. Nitroblue-tetrazolium (NBT)assay results indicate that the extract can reduce superoxide anion generation by 45 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DISMUTATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SUPEROXIDE ANION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROSTAGLANDIN E2 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NITROBLUE-TETRAZOLIUM ASSAY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | 3-D SKIN MODEL |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Horan, I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Clotworthy, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fokunang, C.N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tomkins, P.T. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1vYr6OEx0kA-DPZHDQaGvvef2lkYtDJ0V/view?usp=drivesdk">https://drive.google.com/file/d/1vYr6OEx0kA-DPZHDQaGvvef2lkYtDJ0V/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-9923 | 25.06.2025 | 25.06.2025 | Documentos solicitados |