Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense (Record no. 44193)
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| fixed length control field | 01768nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140622.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-9950 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | J. Nat. Prod., 71(6), p.972-980, 2008 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibited cytotoxic activity when tested in Vitro against L5178Y cells. Chromatographic separation of the extracts yielded 15 natural products, out of which seven were new compounds, with both fungal extracts differing considerably with regard to their secondary metabolites. Compounds 1, 2, 3, 6, and 7 showed cytotoxic activity with EC50 values ranging from 1.7 to 7.8 ìg/mL. When analyzed in Vitro for their inhibitory potential against 24 different protein kinases, compounds 1-3, 5-8, and 15 inhibited several of these enzymes (IC50 values 0.22-9.8 ìg/mL). Interestingly, compounds 1, 3, and 6 were also identified as constituents of an extract derived from healthy leaves of the host plant P. senegalense, thereby indicating that the production of natural products by the endophyte proceeds also under in situ conditions within the plant host. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aly, A.H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Edrada-Ebel, R.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Indriani, I.D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wray, V. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1AB8NJLO7steXZqb6utsd_9yeszMa576i/view?usp=drivesdk">https://drive.google.com/file/d/1AB8NJLO7steXZqb6utsd_9yeszMa576i/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-9950 | 25.06.2025 | 25.06.2025 | Documentos solicitados |