A luminium-induced impairment of Ca modulatory action on GABA transport in brain cortex nerve terminals (Record no. 44232)

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control field 20250625140623.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9990
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245 10 - TITLE STATEMENT
Title A luminium-induced impairment of Ca modulatory action on GABA transport in brain cortex nerve terminals
490 0# - SERIES STATEMENT
Volume/sequential designation Journal of Inorganic BioChemistry, 97(1), p.132-142, 2003
520 3# - SUMMARY, ETC.
Summary, etc. The g-aminobutyric acid (GABA)is the major inhibitory neurotransmitter in vertebrate CNS. At GABAergic synapses, a high-affinity transporter exists, which is responsible for GABA reuptake and release during neurotransmission. GABA transporter activity depends on 21 the phosphorylation / dephosphorylation state, being modulated by Ca /calmodulin-dependent protein phosphatase 2B (calcineurin). 21 Aluminium is known to interfere with the Ca /calmodulin signalling pathway. In this work, we investigate the action of aluminium on GABA translocation mediated by the high-affinity transporter, using synaptic plasma membrane (SPM)vesicles and synaptosomes 21 isolated from brain cortex. Aluminium completely relieved Ca downregulation of GABA transporter, when mediating uptake or release. 21 Accordingly, aluminium inhibited Ca /calmodulin-dependent calcineurin activity present in SPM, in a concentration-dependent manner. The deleterious action of aluminium on the modulation of GABA transport was ascertained by comparative analysis of the aluminium 21 effect on GABA uptake and release, under conditions favouring SPM dephosphorylation (presence of intracellular micromolar Ca ) or 21 phosphorylation (absence of Ca and/or presence of W-7, a selective calmodulin antagonist). In conclusion, aluminium-induced relief of 21 Ca modulatory action on GABA transporter may contribute significantly to modify GABAergic signalling during neurotoxic events in response to aluminium exposure.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALUMINIUM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GABA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CALCINEURIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CA /CAM SIGNALLING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BRAIN CORTEX
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cordeiro, J.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Silva, V.S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Oliveira, C.R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Goncalves, P.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1hptiu2WxnRFf0P_ufRboqcEebGwdOKUU/view?usp=drivesdk">https://drive.google.com/file/d/1hptiu2WxnRFf0P_ufRboqcEebGwdOKUU/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9990 25.06.2025 25.06.2025 Documentos solicitados