Interactions of N-ethylmaleimide and aluminium fluoride with GABA B receptor function in rat neocortical slices (Record no. 44233)

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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-9991
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245 10 - TITLE STATEMENT
Title Interactions of N-ethylmaleimide and aluminium fluoride with GABA B receptor function in rat neocortical slices
490 0# - SERIES STATEMENT
Volume/sequential designation European Journal of Pharmacology, 287(2), p.197-200, 1995
520 3# - SUMMARY, ETC.
Summary, etc. Interactions of N-ethylmaleimide and aluminium fluoride (AlF 4)with GABA B receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABA B receptor agonist baclofen (5-10 /zM)was irreversibly prevented by N-ethylmaleimide (10-50 tzM)and its analog N-phenylmaleimide (10-50 /zM), whilst superfusion of slices with NaF (10 mM)and A1C13 (100 ~M)to form a fluoroaluminate (AIF4-)complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50/~M)and eicosatetraynoic acid (10-50/~M)or the phospholipase A 2 inhibitor bromophenacylbromide (50-100/~M)did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GABA B RECEPTOR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BACLOFEN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NEOCORTICAL SLICE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RAT
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element N-ETHYLMALEIMIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALUMINUM FLUORIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element G-PROTEIN
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ong, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kerr, D.I.B.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1OHnF-X51Igr236EQ13RHCiKkd0vTexay/view?usp=drivesdk">https://drive.google.com/file/d/1OHnF-X51Igr236EQ13RHCiKkd0vTexay/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-9991 25.06.2025 25.06.2025 Documentos solicitados