MARC details
| 000 -LEADER |
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| fixed length control field |
02260nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625140623.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-9993 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Effects of aluminium exposure on brain glutamate and GABA systems: an experimental study in rats |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Food and Chemical Toxicology, 39(12), p.1285-1289, 2001 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
It has been postulated that the neurotoxic effects of aluminium could be mediated through glutamate,an excitatory amino acid. Hence the effects of aluminium administration (at a dose of 4.2 mg/kg body weight daily as aluminium chloride,hexahydrate, intraperitoneally,for 4 weeks)on glutamate and g-amino butyrate (GABA),an inhibitory amino acid, and related enzyme activities in different regions of the brain were studied in albino rats. The glutamate level increased significantly in the cerebrum,thalamic area,midbrain-hippocampal region and cerebellum in response to in vivo aluminium exposure. The aluminium insult also caused significant increases in glutamate a-decarboxylase activity in all the brain regions. However,on aluminium insult,the GABA content was not significantly changed except in the thalamic area,where it was elevated. On the contrary,the GABA-T activities of all the regions were reduced significantly in all regions except the midbrain-hippocampal region. However,the succinic semi-aldehyde content of all brain regions increased,often significantly. The aluminium-induced modification of the enzyme activities may be either due to the direct impact of aluminium or due to aluminium-induced changes in the cellular environment. The aluminiuminduced differential regional accumulation of glutamate or other alterations in enzymes of the glutamate-GABA system may be one of the causes of aluminium-induced neurotoxicity |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ALUMINIUM |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BRAIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GLUTAMATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GAD |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GABA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GABA-T |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SSA |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nayak, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chatterjee, A.K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1z_pSK3ko6BPX8PoO4hGVq9XN0h7NTKYV/view?usp=drivesdk">https://drive.google.com/file/d/1z_pSK3ko6BPX8PoO4hGVq9XN0h7NTKYV/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
