MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02634nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250625140623.0 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-10019 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception |
| 490 0# - SERIES STATEMENT |
|---|
| Volume/sequential designation |
European Journal of Pharmacology, 439(1-3), p.69-75, 2002 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
This study investigates the effect of microinjections of capsaicin in the periaqueductal grey matter of rats on nociceptive behaviour and the possible interactions with NMDA and mGlu receptors. Intra-periaqueductal grey microinjection of capsaicin (1-3-6 nmol/rat)increased the latency of the nociceptive reaction in the plantar test. This effect was prevented by pretreatment with capsazepine (6 nmol/rat), which had no effect per se on the latency of the nociceptive reaction. 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt, 50 nmol/rat)and 2-Methyl-6-(phenylethynyl)pyridine (MPEP, 50 nmol/rat), antagonists of mGlu1 and mGlu5 receptors, respectively, completely blocked the effect of capsaicin. Similarly, pretreatment with DL-2-Amino-5-phosphonovaleric acid (DL-AP5, 5 nmol/rat)and riluzole (4 nmol/ rat), an NMDA receptor antagonist and a voltage-dependent Na+ channels blocker which inhibits glutamate release, respectively, completely antagonized the effect of capsaicin. However, pretreatment with (2S)-a-Ethylglutamic acid (30 nmol/rat)and (RS)-a-Methylserine-O-phosphate (MSOP, 30 nmol/rat), antagonists of group II and group III mGlu receptors, respectively, had no effects on capsaicin-induced analgesia. Similarly, pretreatment with-(piperidin-1-yl)-5-(4-chlophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR 141716A, 5 pmol/rat), a selective cannabinoid CB1 receptor antagonist, did not affect the capsaicin-induced antinociception. In conclusion, this study shows that capsaicin might produce antinociception at the periaqueductal grey level by increasing glutamate release, which activates postsynaptic group I mGlu and NMDA receptors |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
NOCICEPTION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
CAPSAICIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
GLUTAMATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
PERIAQUEDUCTAL GREY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Palazzo, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
De Novellis, V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marabese, I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Cuomo, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rossi, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Berrino, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rossi, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rossi, F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1aWavztZbBmowo_1AMRp5u0zCQi5vupI6/view?usp=drivesdk">https://drive.google.com/file/d/1aWavztZbBmowo_1AMRp5u0zCQi5vupI6/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
