Heparin immobilization onto segmented polyurethaneurea surfaces - effect of hydrophilic spacers (Record no. 44397)
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| fixed length control field | 01917nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140626.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-10158 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Heparin immobilization onto segmented polyurethaneurea surfaces - effect of hydrophilic spacers |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of Biomedical Materials Research, 22, p.977-980, 1988 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Heparin was immobilized onto segmented polyurethane-urea surfaces (Biomer)using hydrophilic poly(ethy1ene oxide)spacers of different chain lengths. The use of the hydrophilic spacer, poly(ethy1ene oxide), reduces protein adsorption and subsequent platelet adhesion on the surface. In addition, the bioactivity of the immobilized heparin is enhanced by the incorporation of these spacers. Immobilized heparin bioactivity is shown to be a function of PEO spacer length. Use of hydrophilic PEO spacers demonstrates that immobilized heparin's bioactivity is consistently higher than that of the Co alkyl spacer, but heparinimmobilized surfaces demonstrate no chain length effect on platelet adhesion, even though they show less platelet adhesion compared to Biomer controls. In the case of PEO-grafted surfaces, platelet adhesion is decreased compared to Biomer controls, and C6 alkyl spacer-grafted surfaces, and exhibits a minimum at I'EO 1000. In ex ziivo A-A shunt experiments under low flow and low shear conditions, all heparinized surfaces exhibit significant prolongation of occlusion times compared to Biomer controls, indicating an ability of immobilized heparin to inhibit thrombosis in whole blood. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Park, K.D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Okano, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nojiri, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kim, S.W. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1yRJ0LCJ8mdCndWpG0hRuXVLkWGXzYk5j/view?usp=drivesdk">https://drive.google.com/file/d/1yRJ0LCJ8mdCndWpG0hRuXVLkWGXzYk5j/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-10158 | 25.06.2025 | 25.06.2025 | Documentos solicitados |