Glycosides in Medicine: "The Role of Glycosidic Residue in Biological Activity" (Record no. 44471)

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control field 20250625140627.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10232
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Title Glycosides in Medicine: "The Role of Glycosidic Residue in Biological Activity"
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Volume/sequential designation Current Medicinal Chemistry, 8(11), p.1303-1328, 2001
520 3# - SUMMARY, ETC.
Summary, etc. Numbers of biologically active compounds are glycosides. Sometimes, the glycosidic residue is crucial for their activity, in other cases glycosylation only improves pharmacokinetic parameters. Recent developments in molecular glycobiology brought better understanding to the aglycone vs. glycoside activities, and made possible to develop new, more active or more effective glycodrugs based on these findings - very illustrative recent example is the story of vancomycin. This paper deals with an array of glycosidic compounds currently used in medicine but also with biological activity of some glycosidic metabolites of the known drugs. It involves glycosides of vitamins, polyphenolic glycosides (flavonoids), alkaloid glycosides, glycosides in the group of antibiotics, glycopeptides, cardiac glycosides, steroid and terpenoid glycosides etc. The physiological role of the glycosyl and structure-activity relations (SAR)in the glycosidic moiety (-ies)are discussed.
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Personal name Kren, V
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Martínková, L.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1GjatD0JZLndLnmINnSqLWi6btVgxg-e9/view?usp=drivesdk">https://drive.google.com/file/d/1GjatD0JZLndLnmINnSqLWi6btVgxg-e9/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10232 25.06.2025 25.06.2025 Documentos solicitados