Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals (Record no. 44535)
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| fixed length control field | 01859nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140629.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-10296 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | The EMBO Journal, 28, p.383-393, 2008 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase f (polf), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with polf dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of polf in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shachar, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ziv, O. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Avkin, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Adar, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wittschieben, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reißner, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaney, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaney, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Carell, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Geacintov, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Livneh, Z. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1Wqf0FvzoMe0XzMNY2ptdW7qTgUVU-8A2/view?usp=drivesdk">https://drive.google.com/file/d/1Wqf0FvzoMe0XzMNY2ptdW7qTgUVU-8A2/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-10296 | 25.06.2025 | 25.06.2025 | Documentos solicitados |