Hundreds of Ankyrin-Like Repeats in Functionally Diverse Proteins: Mobile Modules That Cross Phyla Horizontally? (Record no. 44607)

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fixed length control field 01715nam a2200229Ia 4500
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control field MX-MdCICY
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control field 20250625140630.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10369
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245 10 - TITLE STATEMENT
Title Hundreds of Ankyrin-Like Repeats in Functionally Diverse Proteins: Mobile Modules That Cross Phyla Horizontally?
490 0# - SERIES STATEMENT
Volume/sequential designation PROTEINS: Structure, Function, and Genetics, 17(4), p.363-174, 1993
520 3# - SUMMARY, ETC.
Summary, etc. Based on pattern searches and systematic database screening, almost 650 different ankyrin-like (ANK)repeats from nearly all phyla have been identified; more than 150 of them are reported here for the first time. Their presence in functionally diverse proteins such as enzymes, toxins, and transcription factors strongly suggests domain shuffling, but their occurrence in prokaryotes and yeast excludes exon shuffling. The spreading mechanism remains unknown, but in at least three cases horizontal gene transfer appears to be involved. ANK repeats occur in at least four consecutive copies. The terminal repeats are more variable in sequence. One feature of the internal repeats is a predicted central hydrophobic a-helix, which is likely to interact with other repeats. The functions of the ankyrin-like repeats are compatible with a role in protein-protein interactions.
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Topical term or geographic name entry element SEQUENCE ANALYSIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HOMOLOGY ANK REPEAT
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HORIZONTAL GENE TRANSFER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CELL CYCLE PROTEINS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRANSCRIPTION FACTOR NF-KB
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bork, P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1nEb3WxYJOjhsY1MSQ7gAlCcTV5xlSlzg/view?usp=drivesdk">https://drive.google.com/file/d/1nEb3WxYJOjhsY1MSQ7gAlCcTV5xlSlzg/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10369 25.06.2025 25.06.2025 Documentos solicitados