Anti-cancer activity of targeted pro-apoptotic peptides (Record no. 44666)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01573nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140631.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-10431 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Anti-cancer activity of targeted pro-apoptotic peptides |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Medicine, 5(9), p.1032-1038, 1999 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, and synthesized them by simple peptide chemistry. The 'homing' domain was designed to guide the peptide to targeted cells and allow its internalization. The pro-apoptotic domain was designed to be nontoxic outside cells, but toxic when internalized into targeted cells by the disruption of mitochondrial membranes. Although our prototypes contain only 21 and 26 residues, they were selectively toxic to angiogenic endothelial cells and showed anti-cancer activity in mice. This approach may yield new therapeutic agents. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellerby, H.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arap, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellerby, L.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kain, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Andrusiak, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Del Rio, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Krajewski, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Krajewski, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rao, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ruoslahti, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bredesen, D.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pasqualini, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1V0uSJKqlauuYNS7jPBisTfCoDE7qM1pw/view?usp=drivesdk">https://drive.google.com/file/d/1V0uSJKqlauuYNS7jPBisTfCoDE7qM1pw/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-10431 | 25.06.2025 | 25.06.2025 | Documentos solicitados |