Characterization of Fusarium graminearum Mes1 reveals roles in cell-surface organization and virulence (Record no. 44736)

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control field MX-MdCICY
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control field 20250625140633.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10504
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Title Characterization of Fusarium graminearum Mes1 reveals roles in cell-surface organization and virulence
490 0# - SERIES STATEMENT
Volume/sequential designation Fungal Genetics and Biology, 45(6), p.933-946, 2008
520 3# - SUMMARY, ETC.
Summary, etc. The surfaces of fungal hyphae are mosaics of carbohydrates and cell-surface proteins. Presently, very little is known about the role of these proteins and their organization at the cell surface. Here, we characterize two Fusarium graminearum genes implicated in cell-surface organization, mes1 (FGSG_06680)and pls1 (FGSG_08695). Mes1 is a homologue of mesA, which is required for the formation of stable polarity axes in Aspergillus nidulans. Pls1 encodes a tetraspanin, which belongs to a class of proteins that have been shown to aggregate in membrane rafts along with integrins and other signaling proteins. Our results indicate that Pls1 is dispensable for saprophytic growth and wheat head infection by F. graminearum (a pathogen that does not form appressoria). However, deletion of mes1 reduces sexual and asexual reproduction, severely perturbs the shape of macroconidia and hyphae, alters the pattern of cell wall deposition and the organization of sterol-rich rafts, and attenuates virulence on wheat heads. Our results provide a basis for identifying determinants of fungal virulence that may localize to specialized domains at the cell surface.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FUSARIUM GRAMINEARUM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HYPHAL MORPHOGENESIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element LIPID MICRODOMAINS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MESA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TETRASPANIN
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rittenour, W.R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Harris, S.D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1tZUAkn8jQ4oGkbNRR265KgDn-ZsRAKDt/view?usp=drivesdk">https://drive.google.com/file/d/1tZUAkn8jQ4oGkbNRR265KgDn-ZsRAKDt/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10504 25.06.2025 25.06.2025 Documentos solicitados