Applying in vivo expression technology (IVET)to the fungal pathogen Histoplasma capsulatum (Record no. 44758)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625140633.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10526
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245 10 - TITLE STATEMENT
Title Applying in vivo expression technology (IVET)to the fungal pathogen Histoplasma capsulatum
490 0# - SERIES STATEMENT
Volume/sequential designation Microbial Pathogenesis, 28(3), p.169-182, 2000
520 3# - SUMMARY, ETC.
Summary, etc. Understanding how pathogens survive within the host cell is of paramount importance in the development of vaccines and therapeutic agents. This task has been particularly daunting in the study of fungal pathogens due to the lack of easily manipulated genetic systems. In recent years several molecular genetic reporter systems have been developed to identify genes expressed during the infection process and potential virulence determinants. The development of one method in particular, in vivo expression technology (IVET), has led to the discovery of several genes from various bacterial pathogens necessary for survival during infection. The recent development of molecular genetic tools for Histoplasma capsulatum has enabled us to adapt the IVET technology for this pathogenic fungus utilizing the URA5 gene, which is essential for H. capsulatum survival in mice and in cultured macrophages, as a reporter of in vivo gene expression. We report the first successful application of IVET screening of a fungal pathogen for genes expressed exclusively during infection.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IVET
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FUNGAL
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Topical term or geographic name entry element DIFFERENTIAL GENE EXPRESSION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MOLECULAR GENETICS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Deepe Jr. G.S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Woods, J.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/13aDQ00UbyfJcR3h0LJ9f5vseQKuIfKsN/view?usp=drivesdk">https://drive.google.com/file/d/13aDQ00UbyfJcR3h0LJ9f5vseQKuIfKsN/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10526 25.06.2025 25.06.2025 Documentos solicitados