An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani (Record no. 44787)

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control field MX-MdCICY
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control field 20250625140633.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10555
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Title An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani
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Volume/sequential designation Journal of Antimicrobial Chemotherapy, 14, p.463-475, 1984
520 3# - SUMMARY, ETC.
Summary, etc. A method has been defined for infecting primary mouse peritoneal macrophages with amastigotes of Leishmania donovani in vitro, and analysing the response of the infected macrophages to treatment with drugs. The growth of intracellular amastigotes was inhibited by all clinically used antileishmanial drugs. Toxic effects on macrophages were observed with some drugs. Other experimental antileishmanial compounds were active in this system. This test is proposed as an initial screening test for the discovery of novel antileishmanial compounds.
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Personal name Neal, R.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Croft, S.L.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1e5LjX9kHV9M5Zcv7uSxj7ZSNktCMEQdq/view?usp=drivesdk">https://drive.google.com/file/d/1e5LjX9kHV9M5Zcv7uSxj7ZSNktCMEQdq/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10555 25.06.2025 25.06.2025 Documentos solicitados