Statistical elicitor optimization studies for the enhancement of azadirachtin production in bioreactor Azadirachta indica cell cultivation (Record no. 44841)

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fixed length control field 02346nam a2200241Ia 4500
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control field 20250625140634.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10609
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245 10 - TITLE STATEMENT
Title Statistical elicitor optimization studies for the enhancement of azadirachtin production in bioreactor Azadirachta indica cell cultivation
490 0# - SERIES STATEMENT
Volume/sequential designation BioChemical Engineering Journal, 40(2){b218-226, 2008
520 3# - SUMMARY, ETC.
Summary, etc. Suspension culture of Azadirachta indica produces the biopesticide azadirachtin. Some elicitors (salicylic acid, chitosan, jasmonic acid, methyl jasmonate, yeast extract and yeast extract carbohydrate fraction)at different concentrations were added in shake flask suspension culture of A. indica. Chitosan, salicylic acid and jasmonic acid stimulated the highest increase in azadirachtin content, which ranged from 2 to 3-fold greater than the control. The combined effect of these elicitor(s)on azadirachtin content was then studied by Response Surface Methodology. A synergistic effect of these elicitor(s)on azadirachtin production resulted in 5-fold higher azadirachtin production (15.9 mg/g DCW versus 3.2 mg/g in control cultures). Exposure time studies with elicitor(s)addition on 8th day revealed that highest azadirachtin accumulation reached after 48 h of combined addition of elicitor(s)(17.4 mg/g). Cultivation of A. indica cells was also carried out with combined (statistically optimized)elicitors addition on 8th day in Stirred Tank Bioreactor. This led to more than 3-fold greater azadirachtin accumulation (161.1 mg/l)as opposed to control bioreactor with no elicitor addition (50 mg/l)in 10 days of cultivation period. The present study not only identifies the elicitor(s)and their respective concentrations for enhanced azadirachtin synthesis but also establishes the role of combined elicitors to improve secondary metabolite production of plant cell cultures more efficiently.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element AZADIRACHTIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIOREACTOR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GROWTH KINETICS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ELICITOR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element STATISTICAL DESIGN
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Prakash, G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Srivastava, A.K.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1bEk4UE-fachgw6P72SGZ0K7PKRM9Wthz/view?usp=drivesdk">https://drive.google.com/file/d/1bEk4UE-fachgw6P72SGZ0K7PKRM9Wthz/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10609 25.06.2025 25.06.2025 Documentos solicitados