In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L. (Record no. 44943)

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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10711
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245 10 - TITLE STATEMENT
Title In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.
490 0# - SERIES STATEMENT
Volume/sequential designation Antiviral Research, 37(2), p.121-130, 1998
520 3# - SUMMARY, ETC.
Summary, etc. A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Geranium sanguineum L., was shown to have selective anti-influenza activity in vitro. Expression of HA on the surface of cells infected with A:chicken:Rostock: 34, virus-induced cytopathic effect, infectious virus yield and plaque formation were all reduced at non-toxic concentrations of PC. Synthesis of virus proteins was also selectively inhibited. High concentrations of PC (\200 mg:ml)exhibited a strong virucidal effect. Although the action was directed against an early stage of infection (within 3 h of infection), the process directly affected was not identified. The selectivity of antiviral action was confirmed by the variation in sensitivity of different influenza viruses to PC and the selection of variants with reduced drug sensitivity.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PLANT PREPARATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INFLUENZA VIRUS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INHIBITION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Serkedjieva, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hay, A.J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1GOGJTwJydOefGUkSaam1f1mjysvPuaTD/view?usp=drivesdk">https://drive.google.com/file/d/1GOGJTwJydOefGUkSaam1f1mjysvPuaTD/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10711 25.06.2025 25.06.2025 Documentos solicitados