Natural killer cells kill human melanoma cells with characteristics of cancer stem cells (Record no. 44978)
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| fixed length control field | 02214nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140637.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-10746 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Natural killer cells kill human melanoma cells with characteristics of cancer stem cells |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | International Immunology, 21(7), p.793-801, 2009 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Experimental and clinical data suggest that tumours harbour a cell population retaining stem cell characteristics that can drive tumorigenesis. CD133 is considered an important cancer stem cells (CSC)-associated marker. In a large variety of human malignancies, including melanoma, CD1331 cells have been reported to comprise CSC. In this study, we show that melanoma cell lines are highly heterogeneous for the expression of several stem cell-associated markers including CD133, c-kit/CD117 and p75 neurotrophin receptor/CD271. Since no information is available on the ability of NK cells to recognize and lyse melanoma stem cells, we assessed whether melanoma cell lines, characterized by stem cell-like features, were susceptible to lysis by IL-2-activated NK cells. We show that activated NK cells efficiently kill malignant melanoma cell lines that were enriched in putative CSC by the use of different selection methods (i.e. CD133 expression, radioresistance or the ability to form melanospheres in stem cell-supportive medium). NK cell-mediated recognition and lysis of melanoma cells involved different combinations of activating NK receptors. Since CSC have been reported to be both drug resistant and radioresistant, our present data suggest that NK-based adoptive immunotherapy could represent a novel therapeutic approach to possibly eradicate metastatic melanoma. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pietra, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manzini, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vitale, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Balsamo, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ognio, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Boitano, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Queirolo, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Queirolo, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mingari, M.C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/153PFW4uBRYj8Tay2TGOvWwZqVc5k679x/view?usp=drivesdk">https://drive.google.com/file/d/153PFW4uBRYj8Tay2TGOvWwZqVc5k679x/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-10746 | 25.06.2025 | 25.06.2025 | Documentos solicitados |