MARC details
| 000 -LEADER |
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| fixed length control field |
01948nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625140641.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-10969 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Controlled Release, 65(1-2), p.271-284, 2000 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, defective vascular architecture, impaired lymphatic drainage / recovery system, and greatly increased production of a number of permeability mediators. The phenomenon now known as the enhanced permeability and retention (EPR)effect for lipid and macromolecular agents has been observed to be universal in solid tumors. Primarily, enhanced vascular permeability will sustain an adequate supply of nutrients and oxygen for rapid tumor growth. The EPR effect also provides a great opportunity for more selective targeting of lipid- or polymer-conjugated anticancer drugs, such as SMANCS and PK-1, to the tumor. In the present review, the basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor. Tumor-specific vascular physiology is also described. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TUMOR VASCULAR PERMEABILITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
EPR EFFECT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MACROMOLECULAR THERAPEUTICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PERMEABILITY FACTORS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TUMOR TARGETING |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Maeda, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wu, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sawa, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Matsumura, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hori, K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1ZMHxgdwbCZGo3rIo8NJopdK_GX_x0a8A/view?usp=drivesdk">https://drive.google.com/file/d/1ZMHxgdwbCZGo3rIo8NJopdK_GX_x0a8A/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
