The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa (Record no. 45202)
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| 000 -LEADER | |
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| fixed length control field | 02999nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140641.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-10974 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | European Journal of Pharmaceutical Sciences, 20(1), p.73-81, 2003 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The influence of the surface characteristics of colloidal drug carriers in their interaction with different biological surfaces is becoming increasingly evident. In order to investigate the importance of these characteristics in their interaction with the ocular mucosa, we developed three types of nanocapsules that differ in their surface properties: poly-´-caprolactone (PECL)nanocapsules, chitosan (CS)-coated PECL nanocapsules and poly(ethylene glycol)(PEG)-coated PECL nanocapsules. Two different approaches were used to form these polymer coated nanocapsules: (i)the electrostatic anchorage of the coating onto the PECL nanocapsules-in the case of CS-and (ii)the use of the previously synthesized copolymer PECL-PEG for the formation of the nanocapsules. In both cases, the systems, prepared by the interfacial deposition technique, were loaded with a fluorescent dye (rhodamine)in order to quantify and visualize their interaction with the ocular surface ex vivo and in vivo. An important conclusion from the ex vivo studies is that the developed systems, and specially the CS-coated ones, enhanced the penetration of the encapsulated dye through the cornea. This effect was not simple due to the physical presence of the nanocapsules but to their ability to carry the encapsulated compound. The second conclusion from the confocal laser scanning microscopy (CLSM)studies is that the systems were able to enter the corneal epithelium by a transcellular pathway and that the penetration rate was dependent on the coating composition. The images suggest that the PEG coating accelerates the transport of the nanocapsules across the whole epithelium, whereas the CS coating favours the retention of the nanocapsules in the superficial layers of the epithelium. The specific behaviour of CS-coated systems was also corroborated in vivo. These results indicate that the surface composition of colloidal drug carriers affects their biodistribution in the eye. Therefore, this surface modification approach can be used as a targeting strategy in ocular drug delivery. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | OCULAR DRUG DELIVERY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NANOCAPSULES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHITOSAN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLYETHYLENE GLYCOL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CORNEAL TRANSPORT |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | De Campos, A.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sánchez, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gref, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Calvo, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alonso, M.J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1I9hyK3XVWu3FkJ4qVfDHZp3u-pA_sqsH/view?usp=drivesdk">https://drive.google.com/file/d/1I9hyK3XVWu3FkJ4qVfDHZp3u-pA_sqsH/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-10974 | 25.06.2025 | 25.06.2025 | Documentos solicitados |