Antiprotozoal Lysophospholipid Analogues: A Comparison of their Activity Against Trypanosomatid Parasites and Tumor Cells (Record no. 45299)

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control field 20250625140643.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11072
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Title Antiprotozoal Lysophospholipid Analogues: A Comparison of their Activity Against Trypanosomatid Parasites and Tumor Cells
490 0# - SERIES STATEMENT
Volume/sequential designation Mini-Reviews in Medicinal Chemistry, 4(2), p.141-151, 2004
520 3# - SUMMARY, ETC.
Summary, etc. Lysophospholipid analogues (LPAs), originally developed as anti-cancer agents, have shown significant activity against Leishmania spp. and Trypanosoma cruzi, both in vitro and in vivo. Miltefosine, used as a topical formulation (Miltex.)for metastases, was registered in 2002 for the oral treatment of visceral leishmaniasis. LPAs interfere with lipid synthesis in T. cruzi and cancer cells, but the activity is about >20- fold higher against the parasite.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name De Castro, S.L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Santa-Rita, R.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Urbina, J.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Croft, S.L.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1mEXo5452BfM4Y2Nl9UW0j_6lk4EQPVyD/view?usp=drivesdk">https://drive.google.com/file/d/1mEXo5452BfM4Y2Nl9UW0j_6lk4EQPVyD/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11072 25.06.2025 25.06.2025 Documentos solicitados