Synthesis and in vitro antimycobacterial activity of B-ring modi.ed diaryl ether InhA inhibitors (Record no. 45305)
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| fixed length control field | 01836nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140643.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-11078 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and in vitro antimycobacterial activity of B-ring modi.ed diaryl ether InhA inhibitors |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Bioorganic & Medicinal Chemistry Letters, 18(10), p.3029-3033, 2008 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Previous structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 are nM inhibitors of InhA and inhibit the growth of both sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis with MIC90 values of 1-2 lg/ mL. However, despite their promising in vitro activity, these compounds have ClogP values of over 5. In e.orts to reduce the lipophilicity of the compounds, and potentially enhance compound bioavailability, a series of B ring analogues of 19 were synthesized that contained either heterocylic nitrogen rings or phenyl rings having amino, nitro, amide, or piperazine functionalities. Compounds 3c, 3e, and 14a show comparable MIC90 values to that of 19, but have improved ClogP values. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Am Ende, C.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Knudson, S.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Childs, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sullivan, T.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Boyne, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Knudson, D.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peloquin, C.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Slaydend, R.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tonge, P.J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1t_qV-ZLZlTRaJ3qCERC4lT2zQ01fhu-6/view?usp=drivesdk">https://drive.google.com/file/d/1t_qV-ZLZlTRaJ3qCERC4lT2zQ01fhu-6/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-11078 | 25.06.2025 | 25.06.2025 | Documentos solicitados |