Syntheses and biological activities of daunorubicin analogs with uncommon sugars (Record no. 45307)

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control field MX-MdCICY
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control field 20250625140643.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11080
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Title Syntheses and biological activities of daunorubicin analogs with uncommon sugars
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Volume/sequential designation Bioorganic & Medicinal Chemistry, 13(23)6381-6387, 2005
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Summary, etc. To study the e.ects of the sugar structure on the activity of anthracycline against cancer cells, six daunorubicin analogs containing di.erent uncommon sugars were synthesized. Their cytotoxicities were tested against colon cancer cells by MTS assay. The results showed that the aglycon without sugar moiety has 70-100-fold lower activity against cancer cells than daunorubicin derivatives with various uncommon sugars. It suggests that the sugar structure in daunorubicin plays a critical role in determining its anticancer activity. In the compounds with various sugars, the 40-OH of the sugar is an important determinant for their activity, while the axial-30-substituent in the sugar interferes with the binding of daunorubicins to DNA. Therefore, 2,6-dideoxy sugars are a better choice for generating biologically active daunorubicin analogs than 6-deoxysugars, 2,3,6-trideoxysugars, or 2,3,4,6- tetradeoxysugars.
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Personal name Zhu, L.
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Personal name Cao, X.
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Personal name Chen, W.
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Personal name Zhang, G.
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Personal name Sun, D.
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Personal name Wang, P.G.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1HhE2gg__R9FvdxUrot9Eyxr4omX53e0Z/view?usp=drivesdk">https://drive.google.com/file/d/1HhE2gg__R9FvdxUrot9Eyxr4omX53e0Z/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11080 25.06.2025 25.06.2025 Documentos solicitados