Syntheses and potential anti-prostate cancer activities of ionone-based chalcones (Record no. 45457)

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fixed length control field 01321nam a2200265Ia 4500
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control field MX-MdCICY
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control field 20250625140646.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11230
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Title Syntheses and potential anti-prostate cancer activities of ionone-based chalcones
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Volume/sequential designation Bioorganic & Medicinal Chemistry Letters, 19(4), p.1183-1186, 2009
520 3# - SUMMARY, ETC.
Summary, etc. We report the SAR studies of 43 ionone-based chalcones that demonstrate substantial in vitro anti-proliferative activities in LNCaP, MDA-PCa-2b, 22Rv1, C4-2B and PC-3 prostate cancer cell lines. Compound 25 with an IC50 value of 0.74 lM in LNCaP cells potently antagonizes DHT-induced transactivation of the wild type and the clinically relevant T877A, W741C and H874Y mutated androgen receptors, representing a novel chalcone as pan-antagonist of androgen receptor.
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Topical term or geographic name entry element ANDROGEN RECEPTOR
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Topical term or geographic name entry element MUTATION
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Topical term or geographic name entry element ANTIANDROGEN
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Topical term or geographic name entry element PAN-ANTAGONIST
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Topical term or geographic name entry element IONONE DERIVATIVES
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhou, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Geng, G.
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Personal name Batist, G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hui Wua, J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1qNVZDmPhkisQ0Nwhziqyx1RTDbnexKIo/view?usp=drivesdk">https://drive.google.com/file/d/1qNVZDmPhkisQ0Nwhziqyx1RTDbnexKIo/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11230 25.06.2025 25.06.2025 Documentos solicitados