Simple and reproducible HPLC-DAD-ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots (Record no. 45459)

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fixed length control field 01796nam a2200301Ia 4500
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control field MX-MdCICY
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control field 20250625140646.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11233
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Title Simple and reproducible HPLC-DAD-ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots
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Volume/sequential designation Journal of Pharmaceutical and Biomedical Analysis, 51(2010), p.65-69, 2009
520 3# - SUMMARY, ETC.
Summary, etc. Catharanthus roseus is one of the most important medicinal plants worldwide. The leaves of this species are the only source of the indolomonoterpenic alkaloids vincristin (leurocristine)and vinblastin (vincaleucoblastine), whose anticancer activity represents powerful therapeutics to many diseases, such as Hodgkin lymphoma. Usually, the remaining plant parts go to waste. Here we describe a phytochemical study on this species roots. Alkaloids in aqueous extracts, the usual form of consumption of this matrix, were studied using HPLC-DAD-ESI-MS/MS, which allowed the identification of 19-S-vindolinine, vindolinine, ajmalicine and an ajmalicine isomer, tabersonine, catharanthine, serpentine and a serpentine isomer. Quantification of the identified compounds revealed that serpentine and its isomer were predominant (64.7
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CATHARANTHUS ROSEUS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ROOTS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HPLC-DAD-ESI-MS/MS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALKALOIDS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ferreres, F.
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Personal name Pereira, D.M.
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Personal name Valentao, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Oliveira, J.M.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Faria, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gaspar, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sottomayor, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sottomayor, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1AW6z4VqU1HYU6Yvl_6g65UMW3art5iKY/view?usp=drivesdk">https://drive.google.com/file/d/1AW6z4VqU1HYU6Yvl_6g65UMW3art5iKY/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11233 25.06.2025 25.06.2025 Documentos solicitados