MARC details
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02630nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625140649.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-11373 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Curr. Med. Chem. - Anti-Cancer Agents, 5(3), p.239-249, 2005 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Sesquiterpene lactones (SLs)are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases. In recent years, the anti-cancer property of various SLs has attracted a great deal of interest and extensive research work has been carried out to characterize the anti-cancer activity, the molecular mechanisms, and the potential chemopreventive and chemotherapeutic application of SLs. In this review, we attempt to summarize the current knowledge of the anti-cancer properties of SLs by focusing on the following important issues. First, we discuss the structure-activity relationship of SLs. All SLs contain a common functional structure, an a- methylene-g-lactone group, and this important chemical characteristic means that the thiol-reactivity of SLs is an underlying mechanism responsible for their bioactivities. Second, we assess the experimental evidence for the anti-cancer function of SLs obtained from both in vitro cell culture and in vivo animal models. Various SLs have been demonstrated to execute their anti-cancer capability via inhibition of inflammatory responses, prevention of metastasis and induction of apoptosis. Thirdly, we outline the molecular mechanisms involved in the anti-cancer activity of SLs, in particular, the SLthiols reaction, the effect of SLs on cell signaling pathways such as nuclear transcription factor-kappaB (NF-kB)and mitogen-activated protein kinases (MAPK). Finally, we recapitulate some important SLs with regards to their anti-cancer activities and their potential in anti-cancer drug development. Taken together, many SLs are emerging as promising anticancer agents with potential applications in both cancer chemotherapy and chemoprevention. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SESQUITERPENE LACTONES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTI-CANCER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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APOPTOSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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THIOLS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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ANTI-INFLAMMATORY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NF-KB |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Won, Y.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ong, C.N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Shen, H.M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1xUxje0H6tc4hAYMbuGQUg66WfLCrN2Vr/view?usp=drivesdk">https://drive.google.com/file/d/1xUxje0H6tc4hAYMbuGQUg66WfLCrN2Vr/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
