Synthesis of a Molecularly Imprinted Polymer for the Solid-phase Extraction of Betulin and Betulinic Acid from Plane Bark (Record no. 45809)

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control field 20250625140653.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11593
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245 10 - TITLE STATEMENT
Title Synthesis of a Molecularly Imprinted Polymer for the Solid-phase Extraction of Betulin and Betulinic Acid from Plane Bark
490 0# - SERIES STATEMENT
Volume/sequential designation PhytoChemical Analysis, 21(2), p.180-185, 2010
520 3# - SUMMARY, ETC.
Summary, etc. Plant extracts are usually complex mixtures of various polarity compounds and their study often includes a purifi cation step, such as solid-phase extraction (SPE), to isolate interest compounds prior analytical investigations. Molecularly imprinted polymers (MIPs)are a new promising type of SPE material which off er tailor-made selectivity for the extraction of trace active components in complex matrices. Numerous specifi c cavities that are sterically and chemically complementary of the target molecules, are formed in imprinted polymers. A molecularly imprinted polymer (MIP)was synthesised in order to trap a specifi c class of triterpene, including betulin and betulinic acid from a methanolic extract of plane bark. Methodology - Imprinted polymers were synthesised by thermal polymerisation of betulin as template, methacrylic acid (MAA)or acrylamide (AA)as functional monomer, ethylene glycol dimethacrylate as crosslinking agent and chloroform as porogen. Afterwards, MAA- and AA-MIPs were compared with their non-imprinted polymers (NIPs)in order to assess the selectivity vs betulin and its derivatives. Recovered triterpenes were analysed by HPLC during MIP-SPE protocol. Results - After SPE optimisation, the MAA-imprinted polymer exhibited highest selectivity and recovery (better than 70
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MOLECULARLY IMPRINTED POLYMER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MIP
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Topical term or geographic name entry element SOLID-PHASE EXTRACTION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SPE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BETULIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BETULINIC ACID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRITERPENE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PLANE BARK EXTRACT
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Claude, B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Viron-Lamy, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Haupt, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Morin, P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1KY-I4CuFUF3r1iRzwDr1k9SIj7GbqTlB/view?usp=drivesdk">https://drive.google.com/file/d/1KY-I4CuFUF3r1iRzwDr1k9SIj7GbqTlB/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11593 25.06.2025 25.06.2025 Documentos solicitados