Stressed Jerusalem artichoke tubers (Helianthus tuberosus L.)excrete a protein fraction with specific cytotoxicity on plant and animal tumour cell (Record no. 45896)

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control field MX-MdCICY
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control field 20250625140655.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11680
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245 10 - TITLE STATEMENT
Title Stressed Jerusalem artichoke tubers (Helianthus tuberosus L.)excrete a protein fraction with specific cytotoxicity on plant and animal tumour cell
490 0# - SERIES STATEMENT
Volume/sequential designation Biochimica et Biophysica Acta General Subjects, 1770(9), p.1324-1330, 2007
520 3# - SUMMARY, ETC.
Summary, etc. Wounds from Jerusalem artichoke (Helianthus tuberosus L.)tubers excrete bioactive metabolites from a variety of structural classes, including proteins. Here we describe a protein specifically active against tumour cells arising either from human, animal or plant tissues. The non-tumour animal cells or the plant callus cells are not sensitive to these excreta. The active product was only obtained after a wound-drought stress of plant tubers. The cytotoxicity varies according to the tumour cell type. For instance, some human tumour cell lines and especially the human mammary tumour cells MDA-MB-231 were shown to be very susceptible to the active product. The active agent is shown to contain an 18-kDa polypeptide with homology to a superoxide dismutase (SOD). A 28-kDa polypeptide, related to an alkaline phosphatase (AP), was shown to be tightly linked to this 18-kDa polypeptide. The excreted 28-kDa polypeptide also displayed a consensus sequence similar to the group of DING proteins, but with a smaller molecular weight. The superoxide dismutase polypeptide was shown to be involved in the antitumour activity, but the presence of smaller factors (MWb10 kDa), such as salicylic acid, can enhance this activity.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HELIANTHUS TUBEROSUS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PLANT STRESS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SUPEROXIDE DISMUTASE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALKALINE PHOSPHATASE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TUMOUR
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Griffaut, B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Debiton, E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Madelmont, J.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Maurizis, J.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ledoigt, G.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1Iv9k3wqI2NLOUgUZhQcFRdwoAHSWXbZn/view?usp=drivesdk">https://drive.google.com/file/d/1Iv9k3wqI2NLOUgUZhQcFRdwoAHSWXbZn/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11680 25.06.2025 25.06.2025 Documentos solicitados