Snake Venom Phospholipase A2 Inhibitors: Medicinal Chemistry and Therapeutic Potential (Record no. 45969)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02288nam a2200325Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140656.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-11753 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Snake Venom Phospholipase A2 Inhibitors: Medicinal Chemistry and Therapeutic Potential |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Current Topics in Medicinal Chemistry, 7(8), p.743-756, 2007 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Phospholipases A2 (PLA2s)are commonly found in snake venoms from Viperidae, Hydrophidae and Elaphidae families and have been extensively studied due to their pharmacological and physiopathological effects in living organisms. This article reports a review on natural and artificial inhibitors of enzymatic, toxic and pharmacological effects induced by snake venom PLA2s. These inhibitors act on PLA2s through different mechanisms, most of them still not completely understood, including binding to specific domains, denaturation, modification of specific amino acid residues and others. Several substances have been evaluated regarding their effects against snake venoms and isolated toxins, including plant extracts and compounds from marine animals, mammals and snakes serum plasma, in addition to poly or monoclonal antibodies and several synthetic molecules. Research involving these inhibitors may be useful to understand the mechanism of action of PLA2s and their role in envenomations caused by snake bite. Furthermore, the biotechnological potential of PLA2 inhibitors may provide therapeutic molecular models with antiophidian activity to supplement the conventional serum therapy against these multifunctional enzymes. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PHOSPHOLIPASES A2 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PHOSPHOLIPASE A2 INHIBITORS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NATURAL AND ARTIFICIAL INHIBITORS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SNAKE VENOMS. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marcussi, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sant'Ana, C.D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oliveira, C.Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Quintero Rueda, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Menaldo, D.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beleboni, R.O. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stabeli, R.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stabeli, R.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fontes, M.R.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soares, A.M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1hjPlFoxC_EzZzJlq7mtIse5MY7JP1iUF/view?usp=drivesdk">https://drive.google.com/file/d/1hjPlFoxC_EzZzJlq7mtIse5MY7JP1iUF/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-11753 | 25.06.2025 | 25.06.2025 | Documentos solicitados |