Inhibition of Mycobacterial Growth by Plumbagin Derivatives (Record no. 46077)

MARC details
000 -LEADER
fixed length control field 01894nam a2200301Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625140658.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11862
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245 10 - TITLE STATEMENT
Title Inhibition of Mycobacterial Growth by Plumbagin Derivatives
490 0# - SERIES STATEMENT
Volume/sequential designation Chem Biol Drug Des, 76(1), p.34-42, 2010
520 3# - SUMMARY, ETC.
Summary, etc. Electron transport and respiratory pathways are active in both latent and rapidly growing mycobacteria and remain conserved in all mycobacterial species. In mycobacteria, menaquinone is the sole electron carrier responsible for electron transport. Menaquinone biosynthesis pathway is found to be essential for the growth of mycobacteria. Structural analogs of the substrate or product of this pathway are found to be inhibitory for the growth of Mycobacterium smegmatis and M. tuberculosis. Several plumbagin [5-hydroxy- 2-methyl-1, 4-naphthaquinone]derivatives have been analyzed for their inhibitory effects of which butyrate plumbagin was found to be most effective on M. smegmatis mc2155, whereas crotonate plumbagin showed greater activity on M. tuberculosis H37Rv. Effect on electron transport and respiration was demonstrated by butyrate plumbagin inhibiting oxygen consumption in M. smegmatis. Structural modifications of these molecules can further be improved upon to generate new molecules against mycobacteria.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FIC
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INHIBITION
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Topical term or geographic name entry element M. SMEGMATIS
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Topical term or geographic name entry element MENAQUINONE
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Topical term or geographic name entry element MIC
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PLUMBAGIN
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mathew, R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kruthiventi, N.K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Prasad, J.V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kumar, S.P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Srinu, G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chatterji, D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1VQFRkt7WNGg4Z33PrZ8ptRACLXDI0HQk/view?usp=drivesdk">https://drive.google.com/file/d/1VQFRkt7WNGg4Z33PrZ8ptRACLXDI0HQk/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11862 25.06.2025 25.06.2025 Documentos solicitados