Preparation and characterization of biodegradable nanoparticles based on amphiphilic poly(3-hydroxybutyrate)-poly(ethylene glycol)- poly(3-hydroxybutyrate)triblock copolymer (Record no. 46081)

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control field 20250625140658.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11866
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Title Preparation and characterization of biodegradable nanoparticles based on amphiphilic poly(3-hydroxybutyrate)-poly(ethylene glycol)- poly(3-hydroxybutyrate)triblock copolymer
490 0# - SERIES STATEMENT
Volume/sequential designation European Polymer Journal, 42(10), p.2211-2220, 2006
520 3# - SUMMARY, ETC.
Summary, etc. Amphiphilic triblock copolymers of poly(3-hydroxybutyrate)-poly(ethylene glycol)-poly(3-hydroxybutyrate)(PHB- PEG-PHB)were directly synthesized by the ring-opening copolymerization of b-butyrolactone monomer using PEG as macroinitiator. Their structure, thermal properties and crystallization were investigated by 1H NMR, differential scanning calorimetry (DSC)and X-ray diffraction. It was found that both PHB and PEG blocks were miscible. With the increase in the PHB block length, the triblock copolymers became amorphous because amorphous PHB block remarkably depressed the crystallization of the PEG block. Biodegradable nanoparticles with core-shell structure were prepared in aqueous solution from the amphiphilic triblock copolymers, and characterized by 1H NMR, SEM and fluorescence. The hydrophobic PHB segments formed the central solid-like core, and stabilized by the hydrophilic PEG block. The nanoparticle size was close related to the initial concentrations of the nanoparticle dispersions and the compositions of the triblock copolymers. Moreover, the PHB-PEG-PHB nanoparticles also showed good drug loading properties, which suggested that they were very suitable as delivery vehicles for hydrophobic drugs.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element POLY(3-HYDROXYBUTYRATE)
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRIBLOCK COPOLYMER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element AMPHIPHILIC
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NANOPARTICLE
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chen, Ch.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Him Yu, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chung Cheng, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yu, P.H.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ken Cheung, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1KuS1jupMM0A1bXc3m8vBxnbXRMcpclP0/view?usp=drivesdk">https://drive.google.com/file/d/1KuS1jupMM0A1bXc3m8vBxnbXRMcpclP0/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11866 25.06.2025 25.06.2025 Documentos solicitados