Gymnochromes E and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid, Holopus rangii (Record no. 46165)

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control field MX-MdCICY
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control field 20250625140700.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11952
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Title Gymnochromes E and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid, Holopus rangii
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Volume/sequential designation J. Nat. Prod., 73(4), p.712-715, 2010
520 3# - SUMMARY, ETC.
Summary, etc. Bioactivity-guided fractionation of metabolites from the crinoid Holopus rangii led to the discovery of two new phenanthroperylenequinone derivatives, gymnochromes E (1)and F (2). Gymnochrome E showed cytotoxic activity toward the NCI/ADR-Res with an IC50 of 3.5 ìM. It also inhibited histone deacetylase-1 with an IC50 of 3.3 ìM. Gymnochrome F was a moderate inhibitor of myeloid cell leukemia sequence 1 (MCL-1)binding to Bak. Two anthraquinone metabolites, emodic acid (4)and its new bromo derivative (5), were also isolated from the crinoid and show remarkable similarity to the phenanthroperylenequinone core, suggesting that these metabolites share the same polyketide biosynthetic pathway.
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Personal name Kemami Wangun, H.V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wood, A.
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Personal name Fiorilla, C.
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Personal name Reed, J.K.
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Personal name Mccarthy, P.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wright, A.E.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1I0lIamAPw6Y3GliBtV-RQRWqhM9r9lG0/view?usp=drivesdk">https://drive.google.com/file/d/1I0lIamAPw6Y3GliBtV-RQRWqhM9r9lG0/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11952 25.06.2025 25.06.2025 Documentos solicitados