New Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic Compounds from the Jamaican Sponge Smenospongia aurea (Record no. 46166)

MARC details
000 -LEADER
fixed length control field 01847nam a2200241Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625140700.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11953
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title New Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic Compounds from the Jamaican Sponge Smenospongia aurea
490 0# - SERIES STATEMENT
Volume/sequential designation J. Nat. Prod., 65(4), p.476-480, 2002
520 3# - SUMMARY, ETC.
Summary, etc. In addition to the sesquiterpene-phenol aureols (1), 6¢-chloroaureol (2), and aureol acetate (3), eight indole alkaloids including the new N-3¢-ethylaplysinopsin (9)have been isolated from the Jamaican sponge Smenospongia aurea. Makaluvamine O (10), a new member of the pyrroloiminoquinone class, was also isolated. The structures were characterized by spectroscopic methods, and two new derivatives of aureol were prepared to optimize the biological activity. Aureol N,N-dimethyl thiocarbamate (1a)and 6-bromoaplysinopsin (7)exhibit significant antimalarial and antimycobacterial activity in vitro. Compound 6 showed activity against the Plasmodium enzyme plasmepsin II. The 6-bromo-2¢-de-N-methylaplysinopsin (6), 6-bromoaplysinopsin (7), and N-3¢-ethylaplysinopsin (9)displaced high-affinity [3H]antagonist ligands from cloned human serotonin 5-HT2 receptor subtypes, whereas the other compounds tested did not. Remarkably, the 6-bromo-2¢-de-N-methylaplysinopsin (6)showed a >40-fold selectivity for the 5-HT2C subtype over the 5-HT2A subtype.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hu, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Schetz, J.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kelly, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Peng, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ang, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Flotow, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Leong, C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1x_VDuMR1kvoXtQtDmvxmBQ6S6vlS4N3I/view?usp=drivesdk">https://drive.google.com/file/d/1x_VDuMR1kvoXtQtDmvxmBQ6S6vlS4N3I/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11953 25.06.2025 25.06.2025 Documentos solicitados