HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis (Record no. 46167)

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fixed length control field 01276nam a2200229Ia 4500
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control field MX-MdCICY
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control field 20250625140700.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-11954
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Title HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis
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Volume/sequential designation J. Nat. Prod., 71(9), p.1634-1636, 2008
520 3# - SUMMARY, ETC.
Summary, etc. Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in Vitro with IC50 values of 1.46, >18, and 1.19 ìM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 ìg/mL).
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Personal name Bokesch, H.R.
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Personal name Wamiru, A.
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Personal name Le Grice, S.
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Personal name Beutler, J.A.
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Personal name Mckee, T.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mcmahon, J.B.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1OlrTbWnZZaZPVE9V3X6zBg3ocNbGWwzI/view?usp=drivesdk">https://drive.google.com/file/d/1OlrTbWnZZaZPVE9V3X6zBg3ocNbGWwzI/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-11954 25.06.2025 25.06.2025 Documentos solicitados