NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers (Record no. 46168)
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| fixed length control field | 01852nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140700.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-11955 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | J. Nat. Prod., 72(3), p.443-449, 2009 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The overexpression of the Mcl-1 protein in cancerous cells results in the sequestering of Bak, a key component in the regulation of normal cell apoptosis. Our investigation of the ability of marine-derived small-molecule natural products to inhibit this protein-protein interaction led to the isolation of several bioactive oxy-polyhalogenated diphenyl ethers. A semipure extract, previously obtained from Dysidea (Lamellodysidea)herbacea and preserved in our repository, along with an untouched Dysidea granulosa marine sponge afforded 13 distinct oxy-polyhalogenated diphenyl ethers. Among these isolates were four new compounds, 5, 6, 10, and 12. The structure elucidation of these molecules was complicated by the plethora of structural variants that exist in the literature. During dereplication, we established a systematic method for analyzing this class of compounds. The strategy is governed by trends in the 1H and 13C NMR shifts of the aromatic rings, and the success of the strategy was checked by X-ray crystal structure analysis. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Calcul, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chow, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oliver, A.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tenney, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | White, K.N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wood, A.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fiorilla, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fiorilla, C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1GroCp-dW8R1ZNept8rfvfBlRw_UG5wKy/view?usp=drivesdk">https://drive.google.com/file/d/1GroCp-dW8R1ZNept8rfvfBlRw_UG5wKy/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-11955 | 25.06.2025 | 25.06.2025 | Documentos solicitados |