Peripheral nerve regeneration with sustained release of poly(phosphoester)microencapsulated nerve growth factor within nerve guide conduits (Record no. 46300)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02542nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140703.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-12089 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Peripheral nerve regeneration with sustained release of poly(phosphoester)microencapsulated nerve growth factor within nerve guide conduits |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | BioMaterials, 24(13), p.2405-2412, 2003 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Prolonged delivery of neurotrophic proteins to the target tissue is valuable in the treatment of various disorders of the nervous system. We have tested in this study whether sustained release of nerve growth factor (NGF)within nerve guide conduits (NGCs), a device used to repair injured nerves, would augment peripheral nerve regeneration. NGF-containing polymeric microspheres fabricated from a biodegradable poly(phosphoester)(PPE)polymer were loaded into silicone or PPE conduits to provide for prolonged, site-specific delivery of NGF. The conduits were used to bridge a 10mm gap in a rat sciatic nerve model. Three months after implantation, morphological analysis revealed higher values of fiber diameter, fiber population and fiber density and lower Gratio at the distal end of regenerated nerve cables collected from NGF microsphere-loaded silicone conduits, as compared with those from control conduits loaded with either saline alone, BSA microspheres, or NGF protein without microencapsulation. Beneficial effects on fiber diameter, G-ratio and fiber density were also observed in the permeable PPE NGCs. Thus, the results confirm a longterm promoting effect of exogenous NGF on morphological regeneration of peripheral nerves. The tissue-engineering approach reported in this study of incorporation of a microsphere protein release system into NGCs holds potential for improved functional recovery in patients whose injured nerves are reconstructed by entubulation. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NERVE GROWTH FACTOR |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLYMERIC MICROSPHERE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NERVE GUIDE CONDUITS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLY(PHOSPHOESTER) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NERVE REGENERATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yee, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hwang, P.Y.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wan, A.C.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gao, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Boon, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Boon, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leong, K.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, W. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1wPII1_MO5ZClJbEpfPVHuww_Kubaa1A3/view?usp=drivesdk">https://drive.google.com/file/d/1wPII1_MO5ZClJbEpfPVHuww_Kubaa1A3/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-12089 | 25.06.2025 | 25.06.2025 | Documentos solicitados |