Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres (Record no. 46452)
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| fixed length control field | 01747nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625140705.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-12241 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Structural & Molecular Biology, 17, p.1218-1225, 2010 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | During replicative aging of primary cells morphological transformations occur, the expression pattern is altered and chromatin changes globally. Here we show that chronic damage signals, probably caused by telomere processing, affect expression of histones and lead to their depletion. We investigated the abundance and cell cycle expression of histones and histone chaperones and found defects in histone biosynthesis during replicative aging. Simultaneously, epigenetic marks were redistributed across the phases of the cell cycle and the DNA damage response (DDR)machinery was activated. The age-dependent reprogramming affected telomeric chromatin itself, which was progressively destabilized, leading to a boost of the telomere-associated DDR with each successive cell cycle. We propose a mechanism in which changes in the structural and epigenetic integrity of telomeres affect core histones and their chaperones, enforcing a self-perpetuating pathway of global epigenetic changes that ultimately leads to senescence. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Sullivan, R.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kubicek, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schreiber, S.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Karlseder, J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1ahO2dW5Hz5bL8z8s1UH5CIicP6c6dWsV/view?usp=drivesdk">https://drive.google.com/file/d/1ahO2dW5Hz5bL8z8s1UH5CIicP6c6dWsV/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-12241 | 25.06.2025 | 25.06.2025 | Documentos solicitados |