What made sesquiterpene lactones reach cancer clinical trials? (Record no. 46500)

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control field MX-MdCICY
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control field 20250625153850.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12290
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Title What made sesquiterpene lactones reach cancer clinical trials?
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Volume/sequential designation Drug Discovery Today, 15(15-16), p.668-678, 2010
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Summary, etc. Sesquiterpene lactones (SLs)are plant-derived compounds often used in traditional medicine against inflammation and cancer. This review focuses on the chemical and biological properties of SLs that lead to enhanced anticancer and anti-inflammatory effects. The chemical properties comprise alkylating center reactivity, lipophilicity, and molecular geometry and electronic features. SLs in clinical trials are artemisinin, thapsigargin and parthenolide and many of their synthetic derivatives. These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them head compounds in cancer clinical trials.
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Personal name Ghantous, A.
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Personal name Gali-Muhtasib, H.
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Personal name Vuorela, H.
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Personal name Saliba, N.A.
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Personal name Darwiche, N.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1cW59fERkdG14w3Ko3h_ioXdQDpAKty_3/view?usp=drivesdk">https://drive.google.com/file/d/1cW59fERkdG14w3Ko3h_ioXdQDpAKty_3/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12290 25.06.2025 25.06.2025 Documentos solicitados