MARC details
| 000 -LEADER |
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| fixed length control field |
02460nam a2200325Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625153852.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-12371 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Calmodulin inhibitors from the fungus Emericella sp. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Bioorganic & Medicinal Chemistry, 17(6), p.2167-2174, 2009 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Two new xanthones identified as 15-chlorotajixanthone hydrate (1)and 14-methoxytajixanthone (2)were isolated from an Emericella sp. strain 25379 along with shamixanthone (3)and tajixanthone hydrate (4). The stereostructures of 1 and 2 were elucidated by spectroscopic and molecular modeling methods. The absolute configuration at the stereogenic centers of 1 was established according to CD measurements. In the case of 2, however, the absolute configuration at C-20 and C-25 was designated as S and R, respectively, by Mosher ester methodology. Thereafter, the configuration at C-14 and C-15 of 2 was established as S and S, respectively by comparing the optical rotation and 1H-1H coupling constant experimental values with those obtained through molecular modeling calculations at DFT B3LYP/DGDZVP level of theory for diasteroisomers 2a-2d. The activation of the calmodulin-sensitive cAMP phosphodiesterase (PDE1)was inhibited in the presence of 1-4 in a concentration-dependent manner. The effect of compounds 2 (IC50 = 5.54 lM)and 4 (IC50 = 5.62 lM)was comparable with that of chlorpromazine (CPZ; IC50 = 7.26 lM), a well known CaM inhibitor used as a positive control. The inhibition mechanism of both compounds was competitive with respect to CaM according to a kinetic study. A docking analysis with 2 and 4 using the AutoDock 4.0 program revealed that they interacted with CaM in the same pocket as trifluoropiperazine (TFP). |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
EMERICELLA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
15-CHLOROTAJIXANTHONE HYDRATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
14-METHOXYTAJIXANTHONE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SHAMIXANTHONE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TAJIXANTHONE HYDRATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CALMODULIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DOCKING |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Figueroa, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
González, M.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rodríguez-Sotres, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sosa-Peinado, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
González-Andrade, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Cerda-García-Rojas, C.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mata, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1TmqZ5JCdqlo1Z_mMC0OvpQkrP1t2dLe7/view?usp=drivesdk">https://drive.google.com/file/d/1TmqZ5JCdqlo1Z_mMC0OvpQkrP1t2dLe7/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
